Therapeutic drug monitoring and dose adaptation of cisplatin in a newborn with hepatoblastoma: a case report.

Fabienne Thomas Gareth J Veal Souleiman El BalkhiThierry LafontNicolas Picard Laurence Brugieres Étienne ChatelutChristophe Piguet

Published in: Cancer chemotherapy and pharmacology (2018)

Our study provides useful data on the pharmacokinetics of cisplatin monotherapy in neonates treated within the first few weeks of life. These data provide a reference point to support clinicians in determining appropriate dosing regimens for neonates and support the implementation of therapeutic drug monitoring in such challenging patients.

Keyphrases

newly diagnosed
end stage renal disease
electronic health record
ejection fraction
big data
low birth weight
healthcare
primary care
prognostic factors
peritoneal dialysis
palliative care
open label
patient reported outcomes
machine learning
data analysis
preterm birth