A Protumorigenic mDia2-MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts.

Michael Cangkrama Huan Liu James Whipman Maria Zubair Mai Matsushita Michela Di Filippo Manfred Kopf Metello Innocenti Sabine Werner

Published in: Cancer research (2022)

Inhibition of mDia2/MIRO1-mediated mitochondrial positioning in CAFs induces mitochondrial dysfunction and suppresses tumor growth, revealing a promising therapeutic strategy to target tumor-stroma cross-talk.

Keyphrases

oxidative stress
signaling pathway
extracellular matrix