The pro-tumoral and anti-tumoral roles of EphA4 on T regulatory cells and tumor associated macrophages during HNSCC tumor progression.
Sophia CorboDiemmy NguyenShilpa BhatiaLaurel B DarraghKhalid N M AbdelazeemBenjamin Van CourtNicholas A OlimpoJacob GadwaJustin YuChloe HodgsonVon SamediEnrique Sanz GarciaLillian SiuAnthony J SaviolaLynn E HeasleyMichael W KnitzElena B PasqualeSana D KaramPublished in: bioRxiv : the preprint server for biology (2024)
EphA4 in regulatory T cells has a pro-tumoral effect while EphA4 in macrophages plays an anti-tumoral role underscoring the necessity of developing biologically rational therapeutics.