Higher Analogues of Resorcinarenes and Pyrogallolarenes: Bricks for Supramolecular Chemistry.

Published in: Organic letters (2020)

Easy scalable and eco-friendly syntheses of resorcin[5]arene, pyrogallol[5]arene, (2-nitro)resorcin[5]arene, (2-carboxyl)resorcin[5]arene, and resorcin[7]arene are presented and a wide range of upper-rim modifications is demonstrated. The macrocycles open the door toward expanding the rich covalent and supramolecular chemistry of [4]arenes with analogues having unique 5-fold and 7-fold symmetry.

Keyphrases

water soluble
molecular docking
minimally invasive
drug discovery
molecular dynamics simulations
quantum dots