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Defining thyroid spherules: A benign cytomorphologic feature that mimics microfollicles.

Danielle C CostiganMohanad ShaarMary C FratesErik K AlexanderJustine A BarlettaEdmund S Cibas
Published in: Cancer cytopathology (2019)
Thyroid nodules diagnosed as AUS, if composed predominantly of spherules, are associated with a benign outcome. Recognizing this distinctive cytomorphologic finding may help to reduce the number of FNAs interpreted as AUS and save patients from unnecessary additional testing and surgery.
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