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Isolation of a sleep-promoting compound from Polygonatum sibiricum rhizome.

Kyungae JoHoon KimHyeon-Son ChoiSeung-Su LeeMyun-Ho BangHyung-Joo Suh
Published in: Food science and biotechnology (2018)
The aim of this study was to identify sleep-promoting substance from Polygonatum sibiricum rhizome extract (PSE) with the regulation of sleep architecture. PSE showed a decrease in sleep latency time and an increase in the sleeping time. In the electroencephalography analysis of rats, PSE (150 mg/kg) showed an increase of non-rapid eye movement by 38% and a decrease of rapid eye movement by 31% compared to the control. This sleep-promoting activity was found to be involved in the GABAA-BDZ receptor. The chemical structure of the pure compound was determined by the 1H and 13C nuclear magnetic resonance spectroscopy and gas chromatography mass spectrometry analysis; active compound was glyceryl-1-monolinoleate. The commercial standard glyceryl-1-monolinoleate showed a similar inhibitory concentration on [3H]-flumazenil binding to GABAA-BDZ receptors with final active fraction of PSE. The results indicate that glyceryl-1-monolinoleate is a major active compound responsible for the PSE-derived sleep promotion.
Keyphrases
  • sleep quality
  • physical activity
  • gas chromatography mass spectrometry
  • oxidative stress
  • mass spectrometry
  • high resolution
  • quantum dots
  • binding protein
  • anti inflammatory