Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation.

Anupama TiwariArsalan HashemiaghdamMarissa A LaramieArsalan HashemiaghdamTristaan HaddadMarion I StunaultCarmen BergomAli JavaheriVitaly KlyachkoGhazaleh Ashrafi

Published in: bioRxiv : the preprint server for biology (2023)

. Sirt3 stimulates oxidative ATP synthesis in nerve terminals.Sirt3 sustains the synaptic vesicle cycle in the absence of glucose.

Keyphrases

blood glucose
oxidative stress
ischemia reperfusion injury
metabolic syndrome
peripheral nerve
adipose tissue
prefrontal cortex
insulin resistance