Comprehensive genomic profiling of different subtypes of nasopharyngeal carcinoma reveals similarities and differences to guide targeted therapy.
Siraj M AliMing YaoJicheng YaoJing WangYuwei ChengAlexa B SchrockGung-Wei ChirnHui ChenShuo MuLaurie M GayJulia A ElvinJames SuhVincent A MillerPhilip J StephensJeffrey S RossKai WangPublished in: Cancer (2017)
These results indicate that different NPC subtypes harbor different CRGAs. Both EBV infections and the TMB are associated with the NPC subtypes as well as the alterations of individual genes and pathways. The high frequency of IDH2 mutations in NPUC may facilitate potential targeted therapy and will ultimately point to new therapeutic strategies. Cancer 2017;123:3628-37. © 2017 American Cancer Society.