Effect of levetiracetam on the gene expression of placental transporters in a murine model.
Ricardo Blanco-CastañedaYessica Zapata-VázquezBlanca P Lazalde-RamosDaniel Enríquez-MendiolaIsmael Lares-AsseffCarlos Galaviz-HernándezGerardo MartínezMartha Sosa-MaciasPublished in: Epilepsia (2022)
The repression of the Rfc transcript by LEV at GD 18 suggests that the protein expression would be abolished contributing to the observed intrauterine growth restriction (IUGR). Furthermore, the significant increase in mRNA of xCt, Snat4, Oatp4a1, and Lat1 might be a compensatory mechanism for fetal survival at GD 18.