Pathogenic Th2 Cytokine Profile Skewing by IFN-γ-Responding Vitiligo Fibroblasts via CCL2/CCL8.

Rong JinMiaoni ZhouFuquan LinWen XuAie Xu

Published in: Cells (2023)

Dermal fibroblasts, a principal constituent of skin structure, respond to IFN-γ by skewing T cells towards a type 2 cytokine profile via CCL2 and CCL8, which can be abrogated by JAK inhibitor peficitinib.

Keyphrases

liver fibrosis
liver injury
drug induced
immune response
dendritic cells
extracellular matrix
soft tissue