Multi-omics analysis reveals the influence of genetic and environmental risk factors on developing gut microbiota in infants at risk of celiac disease.

Maureen M LeonardHiren KarathiaMeritxell PujolassosJacopo TroisiFrancesco ValituttiPoorani SubramanianStephanie CamhiVictoria KenyonAngelo ColucciGloria SerenaSalvatore CucchiaraMonica MontuoriBasilio MalamisuraRuggiero FrancavillaLuca ElliBrian FanelliRita ColwellNur HasanAli R ZomorrodiAlessio Fasanonull null

Published in: Microbiome (2020)

Overall, our study provides unprecedented insights into major taxonomic and functional shifts in the developing gut microbiota of infants at risk of CD linking genetic and environmental risk factors to detrimental immunomodulatory and inflammatory effects. Video Abstract.

Keyphrases

risk factors
celiac disease
genome wide
human health
copy number
oxidative stress
life cycle
single cell
dna methylation
climate change