Adipose stromal cells bioproducts as cell-free therapies: manufacturing and therapeutic dose determine in vitro functionality.

Renata SkovronovaEleonora ScacciaSandra Calcat-I-CerveraBenedetta BussolatiTimothy O'BrienKaren Bieback

Published in: Journal of translational medicine (2023)

Our data indicate that the effects of ASC on immunomodulation and angiogenesis are EV-independent. Specific ASC-EV effects need to be dissected for their use as cell-free therapeutics.

Keyphrases

cell free
nlrp inflammasome
circulating tumor
endothelial cells
electronic health record
adipose tissue
insulin resistance
vascular endothelial growth factor
big data
type diabetes
metabolic syndrome
wound healing
data analysis
deep learning
skeletal muscle