A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating.
Xiaoyu NingChristian WirajaDaniel Chin Shiuan LioChenjie XuPublished in: Advanced healthcare materials (2020)
This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).
Keyphrases
- blood glucose
- glycemic control
- type diabetes
- hyaluronic acid
- highly efficient
- reduced graphene oxide
- transition metal
- ion batteries
- emergency department
- blood pressure
- insulin resistance
- high fat diet induced
- weight loss
- metabolic syndrome
- adipose tissue
- liquid chromatography
- mass spectrometry
- ionic liquid
- wound healing
- adverse drug