Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer's Disease Dementia using ELSI-Net.
Max DünnwaldFriedrich KrohnAlessandro SciarraMousumi SarkarAnja SchneiderKlaus FliessbachOkka KimmichFrank JessenAyda RostamzadehWenzel GlanzEnise I IncesoyStefan TeipelIngo KilimannDoreen GoerssAnnika SpottkeJohanna BrustkernMichael T HenekaFrederic BrosseronFalk LüsebrinkDorothea HämmererEmrah DüzelKlaus TönniesSteffen Oeltze-JafraMatthew J BettsPublished in: bioRxiv : the preprint server for biology (2024)
ELSI-Net can be used to assess LC integrity on large- or small-scale studies in Alzheimer's Disease dementia. To ensure robust performance, ELSI-Net should be further evaluated in larger, more diverse datasets comprising varying LC MRI protocols and clinical populations.
Keyphrases
- mild cognitive impairment
- cognitive decline
- magnetic resonance imaging
- contrast enhanced
- cognitive impairment
- simultaneous determination
- machine learning
- diffusion weighted imaging
- deep learning
- mass spectrometry
- magnetic resonance
- liquid chromatography
- solid phase extraction
- case control
- high resolution
- single cell
- gas chromatography