5-Aminosalicylic acid inhibits stem cell function in human adenoma-derived cells: implications for chemoprophylaxis in colorectal tumorigenesis.

Steven William DixonTracey Jane CollardEleanor May Harrisdotter MortenssonDanny Nigel LeggeAdam Christian ChambersAlexander GreenhoughTom Julian CreedAnn Caroline Williams

Published in: British journal of cancer (2021)

5-ASA can suppress the cancer stem phenotype in adenoma-derived cells. Affordable and well-tolerated, 5-ASA is an outstanding candidate as a chemoprophylactic medication to reduce the risk of colorectal polyps and CRC in those at high risk.

Keyphrases

induced apoptosis
cell cycle arrest
endothelial cells
healthcare
endoplasmic reticulum stress
oxidative stress
papillary thyroid
emergency department
cell death
young adults
lymph node metastasis
squamous cell
pi k akt