Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis.

Jin Kyun ParkSehui ShonHyun Jung YooDong-Hyeon SuhDaekwon BaeJieun ShinJae Hyun JunNina HaHyeseung SongYoung Il ChoiThomas PapYeong-Wook Song

Published in: Arthritis research & therapy (2021)

Inhibiting HDAC6 dampens the inflammatory and destructive activity of RA-FLS and reduces the severity of arthritis. Thus, targeting HDAC6 has therapeutic potential.

Keyphrases

histone deacetylase
rheumatoid arthritis
signaling pathway
oxidative stress
disease activity
cancer therapy
interstitial lung disease
idiopathic pulmonary fibrosis