Reduced Efficacy of Glucagon-Like Peptide-1 Receptor Agonists Therapy in People With Type 1 Diabetes and Genetic Forms of Obesity.
Matthew P KleinHalis Kaan AkturkJanet K Snell-BergeonViral N ShahPublished in: Journal of diabetes science and technology (2024)
The weight loss and glycemic lowering effects of GLP-1 RA therapy may be decreased in people with type 1 diabetes and obesity likely related to genetic causes. Further research is needed to understand GLP-1 RA mechanisms via energy regulating genes.
Keyphrases
- weight loss
- type diabetes
- genome wide
- bariatric surgery
- insulin resistance
- metabolic syndrome
- rheumatoid arthritis
- roux en y gastric bypass
- weight gain
- gastric bypass
- high fat diet induced
- copy number
- disease activity
- gene expression
- interstitial lung disease
- skeletal muscle
- adipose tissue
- mesenchymal stem cells
- cell therapy
- systemic sclerosis
- bone marrow