Signaling Switching from Hedgehog-GLI to MAPK Signaling Potentially Serves as a Compensatory Mechanism in Melanoma Cell Lines Resistant to GANT-61.

Nikolina PitešaMatea KurtovićNenad BartoničekDanai S GkotsiJosipa ČonkašTina PetrićVesna Musani Petar Ozretić Natalia A Riobo-Del Galdo Maja Sabol

Published in: Biomedicines (2023)

Our study provides the first ever insights into cell lines resistant to GANT-61 and shows potential mechanisms connected to HH-GLI and MAPK signaling which may represent new hot spots for noncanonical signaling interactions.

Keyphrases

signaling pathway
oxidative stress
pi k akt
risk assessment
climate change
cell proliferation
human health
basal cell carcinoma