Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras.

Tapé KouaméAboua Timothée OkpekonNicaise F BonyAmon Diane N'TamonJean-François GallardSomia RharrabtiKarine LeblancElisabeth MourayPhilippe Grellier Pierre Champy Mehdi A Beniddir Pierre Le Pogam

Published in: Molecules (Basel, Switzerland) (2020)

Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.

Keyphrases

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