Acute Statin Treatment Improves Antibody Accumulation in EGFR- and PSMA-Expressing Tumors.
Patrícia M R PereiraKomal MandleywalaAshwin RagupathiJason S LewisPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
These data show the potential of statins as pharmacologic modulators of endocytic proteins for improved tumors' accumulation of mAbs. The translational significance of these findings lies in the potential of statins to temporarily modulate the heterogeneous presence of receptors at the cell membrane, a characteristic often associated with poor response in tumors to therapeutic antibodies.
Keyphrases
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