Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure.
Flávio A Borges-JúniorDanúbia Silva Dos SantosAcaris BenettiJuliano Z PolidoroAline C T WisniveskyRenato O CrajoinasEdnei L AntônioLeonardo JensenBruno CaramelliGerhard MalnicPaulo J F TucciAdriana Castello Costa GirardiPublished in: Journal of the American Society of Nephrology : JASN (2021)
Prevention of HF progression by EMPA is associated with reduced PT NHE3 activity, restoration of euvolemia, and preservation of renal mass. Moreover, dysregulation of PT SGLT2 may be involved in the pathophysiology of nondiabetic HF.