Neoadjuvant therapy for locally advanced gastric cancer patients. A population pharmacodynamic modeling.
Christophe MassardBelén P SolansDavid CanoJose Carlos SubtilAna ChopiteaLeire ArbeaMaria Dolores LozanoEduardo CastanonIosune BaraibarDiego SalasJose Luis Hernandez-LizoainIñaki F TrocónizJavier RodriguezPublished in: PloS one (2019)
Our model adequately described clinical response profiles, though pathologic response could not be predicted. Although the risk of disease recurrence and survival were linked, the identification of alternative approaches aimed to tailor therapeutic strategies to the individual patient risk warrants further research.