Leptin mediate central obesity on the severity of cardiovascular autonomic neuropathy in well-controlled type 2 diabetes and prediabetes.

Yun-Ru LaiMeng Hsiang ChenWei Che LinWen-Chan ChiuBen-Chung ChengJung-Fu ChenNai-Wen TsaiChih-Cheng HuangCheng-Hsien Lu

Published in: Journal of translational medicine (2020)

Our results highlighted the relationship among leptin, central obesity, and severity of CAN. As the leptin level serves as mediator between central obesity and severity of CAN, a longitudinal study is needed to confirm that control of WC can decrease leptin levels and can be effective in reducing CAN progression.

Keyphrases

type diabetes
insulin resistance
metabolic syndrome
weight loss
high fat diet induced
weight gain
cardiovascular disease
glycemic control
body mass index
heart rate variability