Autoantibodies versus Skin Fibrosis Extent in Systemic Sclerosis: A Case-Control Study of Inverted Phenotypes.
Ashley TieuBenjamin ChaigneBertrand DunoguéJérémie DionAlexis RégentMarion CasadevallPascal CohenPaul LegendreBenjamin TerrierNathalie Costedoat-ChalumeauClaire Le JeunneLuc MouthonPublished in: Diagnostics (Basel, Switzerland) (2022)
ATA lSSc and ACA dSSc have specific characteristics when compared to ATA dSSc or ACA lSSc. ATA lSSc patients have more ILD than ACA lSSc patients, and ATA dSSc patients have the worst prognosis. Overall, inverted phenotypes show the value of a patient assessment combining antibody and skin subset and should be considered as a separate group.