Oncolytic Virotherapy for Melanoma Brain Metastases, a Potential New Treatment Paradigm?

Sauson SoldozyKathleen M Mulligan David X ZhengMelissa A LevoskaChristopher R CullisonTurki ElarjaniDaniel G EichbergLeonel E AmpieAshish H ShahKaan YağmurluMark E ShaffreyJeffrey F ScottRicardo J Komotar

Published in: Brain sciences (2021)

Evidence for oncolytic virotherapy treatment of melanoma is limited primarily to T-VEC, with a noticeable paucity of data in the literature with respect to brain tumor metastasis. Given the promising findings of virotherapy for other brain tumor types, oncolytic virotherapy has great potential to offer benefits to patients afflicted with melanoma brain metastases and warrants further investigation.

Keyphrases

brain metastases
small cell lung cancer
end stage renal disease
ejection fraction
systematic review
machine learning
combination therapy
risk assessment
climate change
big data
basal cell carcinoma