The POZ/BTB and AT-Hook Containing Zinc Finger 1 (PATZ1) Transcription Regulator: Physiological Functions and Disease Involvement.
Monica FedeleElvira CrescenziClaudio ArraPublished in: International journal of molecular sciences (2017)
PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene. Finally, we give some insight on clinical perspectives using PATZ1 as a prognostic marker and therapeutic target.
Keyphrases
- transcription factor
- oxide nanoparticles
- endothelial cells
- stem cells
- oxidative stress
- papillary thyroid
- endoplasmic reticulum stress
- signaling pathway
- cell death
- epithelial mesenchymal transition
- induced pluripotent stem cells
- squamous cell carcinoma
- cell cycle arrest
- peripheral blood
- case control
- amino acid
- dna binding
- childhood cancer