Positional motif analysis reveals the extent of specificity of protein-RNA interactions observed by CLIP.

Klara KuretAram Gustav AmaliettiD Marc JonesCharlotte CapitanchikJernej Ule

Published in: Genome biology (2022)

Our study provides insights into the overall contributions of regional binding preferences, protein domains, and low-complexity regions to the specificity of protein-RNA interactions, and shows the value of cross-motif and cross-RBP comparison for data interpretation. Our results are presented for exploratory analysis via an online platform in an RBP-centric and motif-centric manner ( https://imaps.goodwright.com/apps/peka/ ).

Keyphrases

binding protein
protein protein
amino acid
high throughput
big data
decision making
deep learning
dna binding
single cell