Quantitative assessment of the immune microenvironment in African American Triple Negative Breast Cancer: a case-control study.
Vesal YaghoobiMyrto MoutafiThazin Nwe AungVasiliki PelekanouSanam YaghoubiKim BlenmanEiman IbrahimIoannis A VathiotisSaba ShafiAnup SharmaTess O'MearaAileen I FernandezLajos PusztaiDavid L RimmPublished in: Breast cancer research : BCR (2021)
While the TME in TNBC is rich in immune cells in both racial groups, there is a numerical increase in lymphoid infiltration in AA compared to NAA TNBC. Significantly, higher activated T cells seen in AA patients raises the possibility that there may be a subset of AA patients with improved response to immunotherapy.