RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis.

Xufei ZhangJie WuQinjie LiuXuanheng LiYiyu YangLei WuXiuwen WuYun ZhaoJian-An Ren

Published in: Clinical and translational medicine (2023)

These findings elucidate molecular mechanisms linking necroptosis to the STING pathway, and suggest a potential benefit of therapeutic targeting of necroptosis in STING-driven inflammatory diseases.

Keyphrases

acute kidney injury
intensive care unit
oxidative stress
cancer therapy
septic shock
human health