Login / Signup

The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential.

Aleix Bayona-FeliuAndrés Aguilera
Published in: Molecular & cellular oncology (2021)
Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.
Keyphrases
  • papillary thyroid
  • transcription factor
  • squamous cell
  • genome wide
  • gene expression
  • dna methylation
  • oxidative stress
  • childhood cancer