Essential oils from two Allium species exert effects on cell proliferation and neuroblast differentiation in the mouse dentate gyrus by modulating brain-derived neurotrophic factor and acetylcholinesterase.

Hyo Young JungKwon Young LeeDae Young YooJong Whi KimMiyoung YooSanghee LeeKi-Yeon YooYeo Sung YoonJung Hoon ChoiIn-Koo Hwang

Published in: BMC complementary and alternative medicine (2016)

These results suggest that GO significantly improves novel object recognition as well as increases cell proliferation and neuroblast differentiation, by modulating hippocampal BDNF protein levels and AChE activity, while CO impairs novel object recognition and decreases cell proliferation and neuroblast differentiation, by reducing BDNF protein levels in the hippocampus.

Keyphrases

cell proliferation
cell cycle
working memory
pi k akt
signaling pathway
protein protein
stress induced
binding protein
brain injury