Heterogeneity of childhood acute leukemia with mature B-cell immunophenotype.
Irina DeminaElena ZerkalenkovaOlga IllarionovaYulia OlshanskayaTatiana VerzhbitskayaAlexandra SemchenkovaGrigory TsaurEkaterina RusanovaMargarita BelogurovaLudmila BaidunSvetlana PlyasunovaTatiana KonyuhovaAnna KazakovaLarisa FechinaGalina NovichkovaElena SamochatovaNatalia MyakovaAlexey MaschanAlexander M PopovPublished in: Journal of cancer research and clinical oncology (2019)
In conclusion, our study shows that BIV subtype is heterogeneous group of leukemia including not only the BL, but also BCP-ALL. In ambiguous cases, only a combination of multiple immunophenotypic, cytomorphologic, and genetic diagnostic technologies can allow the precise discrimination of BL and BCP-ALL and selection of the appropriate treatment scheme.