Login / Signup

Durable response to olaparib combined low-dose cisplatin in advanced hepatocellular carcinoma with FANCA mutation: A case report.

Yi-Hsuan LaiKai-Che TungSan-Chi Chen
Published in: Medicine (2022)
We report the first case of FANCA-mutated HCC that responded well to olaparib and low-dose cisplatin. This addressed the potential therapeutic role of DDR gene mutation in HCC and the possible synergistic effect of PARP inhibitor and cisplatin. These findings highlight areas where further investigation and effort are needed.
Keyphrases
  • low dose
  • high dose
  • dna repair
  • cancer therapy
  • drug delivery