FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro.

A Allam MohamedAndreas ThomsenMarie FolloCostantinos ZamboglouPeter BronsertHanan MostafaAber AmenMohamed MekawyAnca L GrosuThomas Baptist Brunner

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2020)

Pharmacological inhibition of FAK in pancreatic cancer could be a novel therapeutic strategy as our results show a radiosensitization effect of VS-4718 in vitro in a multicellular 2D- and in a 3D-model of pancreatic cancer.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell death
oxidative stress
cell proliferation