Theranostic Nanoprobes with Aggregation-Induced NIR-II Emission: from Molecular Design to Biomedical Application.
Yajing JiangLinlin ZhuWenbo WuPublished in: Chembiochem : a European journal of chemical biology (2023)
The development of fluorophores with other powerful features has received much attention for the diagnosis and treatment of diseases. Nanoprobes (NPs) with aggregation-induced emission (AIE) have demonstrated superior performance in deeper penetration depth with better resolution, higher signal-to-noise ratio, and lower side effects in the second near-infrared window (NIR-II, 1000-1700 nm) than in any other range. Herein, the latest advances in NIR-II AIE NPs in cancer theranostics are summarized. In particular, we focus on the design of multifunctional AIE agents with both strong NIR-II emission and effective photothermal conversion or reactive oxygen species (ROS) production, as well as their translational biomedical applications, including imaging diagnosis, image-guided surgery, and image-guided phototherapy, etc. At the end of this review, the opportunities and challenges of this field are also discussed.
Keyphrases
- photodynamic therapy
- fluorescence imaging
- fluorescent probe
- drug release
- living cells
- reactive oxygen species
- drug delivery
- minimally invasive
- high resolution
- cancer therapy
- squamous cell carcinoma
- working memory
- air pollution
- papillary thyroid
- coronary artery disease
- oxide nanoparticles
- surgical site infection
- percutaneous coronary intervention
- metal organic framework