Metabolic profiling shows pre-existing mitochondrial dysfunction contributes to muscle loss in a model of ICU-acquired weakness.

Paul R KempRichard PaulAaron C HinkenDavid NeilAlan RussellMark J Griffiths

Published in: Journal of cachexia, sarcopenia and muscle (2020)

We show that pre-existing mitochondrial dysfunction and reduced cortisol inactivation contribute to muscle loss following surgery. The data also implicate GDF-15 and IL-15RA in mitochondrial dysfunction.

Keyphrases

skeletal muscle
minimally invasive
intensive care unit
coronary artery bypass
rheumatoid arthritis
electronic health record
mechanical ventilation
ankylosing spondylitis
atrial fibrillation
machine learning
data analysis
acute respiratory distress syndrome