SARS-CoV-2 N Protein Triggers Acute Lung Injury via Modulating Macrophage Activation and Infiltration in in vitro and in vivo.

Dengming LaiKun ZhuSisi Li Yi XiaoQi XuYi-Sheng SunPingping YaoDaqing MaQiang Shu

Published in: Journal of inflammation research (2023)

SARS-CoV-2 and its N protein but not S protein induced acute lung injury and systemic inflammation, which was closely related to macrophage activation, infiltration and release cytokines.

Keyphrases

sars cov
lipopolysaccharide induced
lps induced
protein protein
respiratory syndrome coronavirus
binding protein
signaling pathway
inflammatory response
endothelial cells
drug induced
high glucose
small molecule