CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis.
Marc DürrGunnar NissenKurt-Wolfram SühsPhilipp SchwenkenbecherChristian GeisMarius RingelsteinHans-Peter HartungNicolaus KrögerMax KaufmannMichael P MalterMarie MadlenerFranziska S ThalerTania KümpfelMakbule SenelMartin G HäuslerHauke SchneiderFlorian Then BerghChristoph KellinghausUwe K ZettlKlaus-Peter WandingerNico MelzerCatharina C GrossPeter LangeJens DreyhauptHayrettin TumaniFrank LeypoldtJan Lewerenznull nullPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
NMDAR-E and LGI-E differ in their typical extent of CSF inflammation. In addition, the patterns formed by the different inflammatory CSF parameters and their relationship with disease severity, age, and disease duration are subtype-characteristic. Moreover, signs for multiple sclerosis-like chronic inflammation are present in a subgroup of patients with NMDAR-E. These CSF patterns might be markers for the different immunopathogeneses of LGI1-E and NMDAR-E.