Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells.

Lei WuXudong LiuJuan LeiNan ZhangHuakan ZhaoJiangang ZhangHuan DengYongsheng Li

Published in: Journal for immunotherapy of cancer (2023)

These results suggest that Fgl2 plays a role in promoting immune suppression by modulating cholesterol metabolism and targeting Fgl2 combined with PD-1 checkpoint blockade provides a promising therapeutic strategy for antitumor therapy.

Keyphrases

induced apoptosis
low density lipoprotein
cell cycle arrest
dna damage
signaling pathway
endoplasmic reticulum stress
stem cells
oxidative stress
drug delivery