The effect of continuous digital hypothermia on lamellar energy metabolism and perfusion during laminitis development in two experimental models.
Simon M StokesFrancois Rene BertinDarko StefanovskiLea PoulsenJames K BelknapCarlos E Medina TorresChristopher C PollittAndrew William Van EpsPublished in: Equine veterinary journal (2020)
CDH caused a marked decrease in lamellar glucose metabolism (CON, EHC and OF) and perfusion (CON and EHC) without affecting lamellar glucose concentration. Although cellular energy failure is not a primary pathophysiological event in EHC and OF laminitis models, CDH may act by limiting energy supply to pathologic cellular processes whilst preserving those critical to lamellar homoeostasis.