Activation of AdipoR1 with rCTRP9 Preserves BBB Integrity through the APPL1/AMPK/Nrf2 Signaling Pathway in ICH Mice.

Wei Zhao Fanping Kong Xiu Gong Zaiyu Guo Lianhua Zhao Sa Wang

Published in: Oxidative medicine and cellular longevity (2021)

Activation of AdipoR1 with rCTRP9 improved neurological functions and preserved BBB integrity through the APPL1/AMPK/Nrf2 signaling pathway in ICH mice. Therefore, CTRP9 could serve as a promising therapeutic method to alleviate BBB injury following ICH in patients.

Keyphrases

signaling pathway
blood brain barrier
end stage renal disease
oxidative stress
pi k akt
ejection fraction
skeletal muscle
chronic kidney disease
epithelial mesenchymal transition
peritoneal dialysis
prognostic factors
induced apoptosis
type diabetes
cerebral ischemia
protein kinase
brain injury