Contribution of Inflammation and Bone Destruction to Pain in Arthritis: A Study in Murine Glucose-6-Phosphate Isomerase-Induced Arthritis.
Matthias EbbinghausSylvia MüllerGisela Segond von BanchetAnnett EitnerIsabel WankAndreas HessIngrid HilgerThomas KamradtHans-Georg SchaiblePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Pain-related behaviors precede and outlast self-limiting arthritis. In nonremitting arthritis with enhanced bone destruction, mainly local thermal, but not local mechanical, hyperalgesia was aggravated. The up-regulation of ATF-3 indicates an early and persisting affection of sensory neurons by G6PI-induced arthritis.
Keyphrases
- rheumatoid arthritis
- neuropathic pain
- chronic pain
- high glucose
- oxidative stress
- diabetic rats
- pain management
- bone mineral density
- drug induced
- metabolic syndrome
- type diabetes
- blood pressure
- spinal cord injury
- skeletal muscle
- soft tissue
- postmenopausal women
- bone regeneration
- bone loss
- insulin resistance
- endoplasmic reticulum stress