The realization and control of the quantum anomalous Hall (QAH) effect are highly desirable for the development of spintronic and quantum devices. In this work, we propose a van der Waals (vdW) heterostructure of ultrathin MnBi 2 Se 4 and Bi 2 Se 3 layers and demonstrate that it is an excellent tunable QAH platform by using model Hamiltonian and density functional theory simulations. Its band gap closes and reopens as external electric field increases, manifesting a novel topological phase transition with an electric field of ∼0.06 V/Å. This heterostructure has other major advantageous, such as large topological band gap, perpendicular magnetization, and strong ferromagnetic ordering. Our work provides clear physical insights and suggests a new strategy for experimental realization and control of the QAH effect in real materials.