Role of Semaphorin 3A in Kidney Development and Diseases.
Yizhen SangKenji TsujiHiroyuki NakanohKazuhiko FukushimaShinji KitamuraJun WadaPublished in: Diagnostics (Basel, Switzerland) (2023)
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse functions, including immune regulation, cell survival, migration and angiogenesis, thus involving in the several pathogeneses of diseases, including eyes and neurons, as well as kidneys. SEMA3A is expressed in podocytes and tubular cells in the normal adult kidney, and recent evidence has revealed that excess SEMA3A expression and the subsequent signaling pathway aggravate kidney injury in a variety of kidney diseases, including nephrotic syndrome, diabetic nephropathy, acute kidney injury, and chronic kidney disease. In addition, several reports have demonstrated that the inhibition of SEMA3A ameliorated kidney injury via a reduction in cell apoptosis, fibrosis and inflammation; thus, SEMA3A may be a potential therapeutic target for kidney diseases. In this review article, we summarized the current knowledge regarding the role of SEMA3A in kidney pathophysiology and their potential use in kidney diseases.
Keyphrases
- public health
- chronic kidney disease
- acute kidney injury
- signaling pathway
- diabetic nephropathy
- oxidative stress
- healthcare
- mental health
- cardiac surgery
- spinal cord
- epithelial mesenchymal transition
- young adults
- risk assessment
- emergency department
- cell death
- long non coding rna
- electronic health record
- binding protein
- liver fibrosis