SMYD2-mediated TRAF2 methylation promotes the NF-κB signaling pathways in inflammatory diseases.
Weijun WuJinghuan WangChenxi XiaoZhenghua SuHaibi SuWen ZhongJianchun MaoXinhua LiuYi Zhun ZhuPublished in: Clinical and translational medicine (2022)
Our data uncovered an unprecedented cytoplasmic protein network that employed methylation of TRAF2 for the maintenance of NF-κB activation during inflammatory diseases.
Keyphrases
- signaling pathway
- oxidative stress
- pi k akt
- lps induced
- genome wide
- dna methylation
- nuclear factor
- induced apoptosis
- epithelial mesenchymal transition
- electronic health record
- big data
- protein protein
- cell proliferation
- inflammatory response
- small molecule
- toll like receptor
- gene expression
- deep learning
- artificial intelligence