Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination.
Na WangMinghui WangSuren JeevaratnamCassandra RosenbergTadafumi C IkezuFrancis ShueSydney V DossAlla AlnobaniYuka A MartensMelissa WrenYan W AsmannBin ZhangGuojun BuChia-Chen LiuPublished in: Molecular neurodegeneration (2022)
Our findings provide critical mechanistic insights into how apoE isoforms differentially regulate microglial function and the maintenance of myelin dynamics, which may inform novel therapeutic avenues for targeting microglial dysfunctions in neurodegenerative diseases.