The spatial distribution of intermediate fibroblasts and myeloid-derived cells dictate lymph node metastasis dynamics in oral cancer.
Soni ShaikhHarsh DharManju MoorthyVijayalakshmi BhatSangramjit BasuDevmalya BanerjeeDeepak Kumar MishraSourav DattaGeetashree MukherjeePublished in: Journal of translational medicine (2024)
We have generated a functional organization of the tumor-stromal interface in GB-OSCC and identified spatially located genes that contribute to nodal metastasis and disease progression. Our dataset might now be mined to discover suitable molecular targets in oral cancer.
Keyphrases
- lymph node metastasis
- induced apoptosis
- bone marrow
- squamous cell carcinoma
- papillary thyroid
- cell cycle arrest
- dendritic cells
- genome wide
- lymph node
- acute myeloid leukemia
- neoadjuvant chemotherapy
- endoplasmic reticulum stress
- signaling pathway
- oxidative stress
- gene expression
- extracellular matrix
- genome wide identification
- dna methylation
- bioinformatics analysis
- immune response