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Preclinical efficacy investigation of human neutrophil elastase inhibitor sivelestat in animal model of psoriasis.

A S ZhukovV R KhairutdinovA V SamtsovMikhail Yu KrasavinA V Garabadzhiu
Published in: Skin health and disease (2021)
Based on the results obtained using the animal model of imiquimod-induced psoriasis, it was established that the HNE inhibitor sivelestat demonstrated efficacy comparable to that of a strong topical glucocorticoid steroidal drug (betamethasone dipropionate 1%). Significant resolution of skin lesions, reduction of epidermal thickness, diminishing of the skin infiltration with T-lymphocytes and normalization of the cell division rate in epidermis and dermis were evident. Thus, suppression of IL-36 mediated inflammation activity in the skin by topical application of a HNE inhibitor represents a promising new direction in the treatment of psoriasis. Certainly, HNE has other targets; thus, molecular studies could be subject of future experiments beyond the scope of the present study.
Keyphrases
  • wound healing
  • soft tissue
  • endothelial cells
  • oxidative stress
  • cell therapy
  • atopic dermatitis
  • single cell
  • drug induced
  • single molecule
  • emergency department
  • anti inflammatory drugs
  • bone marrow
  • case control