Comparing T Cell Subsets in Broncho-Alveolar Lavage (BAL) and Peripheral Blood in Patients with Advanced Lung Cancer.
Annapaola MarinielloFabrizio TabbòDavide IndellicatiMartina TesauroNicole Alessia RezmivesMaria Lucia RealeAngela ListìEnrica CapellettoSimona CarnioValentina BertagliaCaterina MeccaLorena ConsitoMarco De FilippisMaristella BungaroChiara ParatoreMassimo Di MaioFrancesco PassigliaLuisella RighiDario SangioloSilvia NovelloMassimo GeunaPaolo BironzoPublished in: Cells (2022)
In BAL from advanced LC patients, T cells present features of exhaustion. T cells in t-BAL could be the best surrogate of tumor-infiltrating T cell, and future studies should evaluate T cell phenotype and density as potential biomarkers for cancer immunotherapy outcome.