Cyclophilin A is a ligand for RAGE in thrombo-inflammation.

Peter SeizerSaskia N I von Ungern-SternbergVerena HaugValerie DicentaAnnabelle RosaElke ButtMoritz NöthelAnne-Katrin RohlfingManuel SiglePeter P NawrothClaudia NussbaumMarkus SperandioCharly KuschMara MeubMarkus SauerPatrick MünzerKristin BieberAnna StangerAndreas F MackRené HuberKorbinian BrandMoritz LehnersRobert FeilAntti PosoKonstantin KrutzkeTilman E SchäfferBernhard NieswandtOliver BorstAndreas E MayAlma ZerneckeMeinrad GawazDavid Heinz Mann

Published in: Cardiovascular research (2024)

We propose RAGE as a hitherto unknown receptor for CyPA mediating leukocyte as well as platelet activation. The CyPA-RAGE interaction thus represents a novel mechanism in thrombo-inflammation.

Keyphrases

oxidative stress
peripheral blood